Code: 17AMPPBM Advanced Biomechanics
Lecturer:  Weekly load: 2+2 Assessment: Z,ZK
Department: 17101 Credits: 4 Semester: S
Description:
Students will obtain knowledge of cellular biomechanics, biomechanics of soft and hard tissues, contractile tissues, elements of cardiovascular system, cerebrospinal fluid etc. Students also will be introduced to specialized branches of biomechanics like forensic biomechanics etc. During practices students will take exercise of different techniques and methods used for mathematical modelling and biomechanical properties of living structures measurements.
Contents:
1. Recapitulation (scientific methods in biomechanics, basic concepts in biomechanics)
2. Cellular biomechanics (cellular structure, mechanical properties of cells and its measurement, adhesion)
3. Cellular biomechanics (cell membrane, cell contractility, from cells to organs and advanced biological structures)
4. Passive elements biomechanics (ligaments, tendons, special structures, bones), rheology, viscoelastic properties of ligaments, tendons and bones, bone as living tissue, blood circulation in bone, mechanical properties of passive structure measurement.
5. Passive elements biomechanics ((ligaments, tendons, special structures, bones), Viscoelastic properties of cartilages, lubrication of articulating cartilage, experimental analysis of mechanical properties of cartilage. Constitutive equations of triphasic model of cartilage.
6. Active elements biomechanics (muscles) Crossbridge theory of contraction, Hill and Huxley muscle models.
7. Active elements biomechanics (muscles) other models of muscle contraction, CNS and muscle contraction control.
8. Mechanical properties of cardiovascular system and respiratory system, blood rheology, properties of red blood cells, blood cells and blood vessels wall interaction, thrombus formation, respiration mechanics, erythrocytes and alveolar gases exchanges.
9. Cerebrospinal fluid (CSF) flow, properties, composition and function of CSF. Genesis and absorption of CSF, CSF flow models.
10. Organs biomechanics, mechanical properties of organs, structural collapse, organ injury and healing.
11. Trauma biomechanics, injury and heling of organs, impulse loading and structural response, stress concentration, organs tolerance to impulse loading.
12. Biomechanical aspects of tissue engineering (modelling and remodelling processes), Wolff?s law, Roux concept, fracture healing, remodelling of soft tissues, growth factors, tissue engineering.
13. Forensic biomechanics, biomechanics in crime investigation, traffic accident investigation etc. Forensic biomechanics tools and methods. (External lecture).
14. TEST
Recommended literature:
Povinná literatura:
[1] FUNG, Y. Biomechanics: motion, flow, stress, and growth. New York: Springer-Verlag, 1990, xv, 569 p. ISBN 03-879-7124-6.
[2] FUNG, Y. Biomechanics: mechanical properties of living tissues. 2nd ed. New York: Springer-Verlag, 1993, xviii, 568 p. ISBN 35-409-7947-6.

Doporučená literatura:
[1] KEENER, James P a James SNEYD. Mathematical physiology. New York: Springer, 1998, viii, 766 p. ISBN 03-879-8381-3.
Keywords:
Biomechanics, biomaterials, biocompatibility, bio-tolerance, mechanics of skeletal system, mechanics of ligaments, tendons, mechanics of heard, blood circulation, respiration system, nerve system.