Code: 17AMBAOL Applied Optoelectronics in Medicine
Lecturer: prof.Dr.-Ing.Dr.h.c. Vladimír Bla¾ek Weekly load: 2+2 Assessment: KZ
Department: 17101 Credits: 4 Semester: W
Description:
Scope and aims of non-invasive measurement techniques in medical diagnostics. Fundamental physiology of the human vascular system, venous and arterial hemodynamics, skin anatomy and perfusion. Computer simulation of the cardiovascular system. UV, VIS and IR spectroscopy. Fundamental optics of the eye and colour analysis. Optical parameters of biological tissue. Dispersion of light. Design of optoelectronic sensors. Camera based sensor concepts and optical imaging systems in medicine.
Contents:
1. Course introduction. High frequency techniques and optoelectronics.
Possibilities and measurement systems using optoelectronics in medicine.
2. Light and Life, ecological and bio-physical aspects.
Planet earth in the radiation field of the sun. Optical window of the atmosphere and the tissue.
3. Metrological aspects of optoelectronics, basics of physiological optics
Intensity of radiation, radiometry, photometry. The human eye as high sensitivity detector array.
4. Optoelectronical sensor concepts.
Light sources, detectors, fibre optic components, coherence, polarisation, collimation and focussing of light.
5. Fundamentals of tissue optics, optical parameter of biological probes.
UV, NIS, NIR-spectroscopy, interferometry. Light scattering measurement techniques. Ulbricht-sphere sensor technology.
6. Photon distribution in tissue, optical model of the human skin.
Strategies for analysis and simulation of light interaction with tissue. Maxwell and Radiation transport theory. Kubelka-Munk-Theory. Monte-Carlo-Simulation.
7. Biophysical fundamentals of the human hemodynamics.
Measuring parameters and non-invasive data acquisition concepts. Modelling and simulation of the human vascular system using an electrical model.
8. Modern optoelectronical sensor concepts and their main diagnostical applications.
Fundamentals of photophlethysmography (PPG) for transcutaneous analysis of peripheral hemodynamics. Venous and arterial examination tests. Sensor concepts for cosmic flights applications.
9. Classical optoelectronical imaging techniques for medical diagnostics
Classification and historical remarks. Measurement setups of IR-photography, IR-diaphanoscopy and Laser-Doppler-Perfusion-Imaging and their typical applications.
10. Modern optoelectronical imaging techniques for medical diagnostics.
Fundamentals, concepts and realisation aspects of Photoplethysmography-Imaging (PPGI) and Optical Coherence Tomography (OCT) and their typical applications.
Recommended literature:
[1] Blazek, V., Schultz-Ehrenburg, U.: Quantitative Photoplethysmography. Basic facts and examination tests for evaluating peripheral vascular functions. VDI Verlag, Düsseldorf 1996, ISBN 3-18-319220-9
[2] Bronzio, J.D.: The Biomedical Engineering Handbook. 2nd ed,, Volume I., Springer Verlag, Heidelberg 2000, ISBN 3-540-66351-7
[3] Cheong, W.F. et al.: A rewiew of the optical properties of biological tissue. QE 26 (1990), 2166-2185
[4] Cooper, J., Cass, T. (eds): Biosensors. 2nd ed., Oxford University Press, Oxford 2004, ISBN 0-19-963846-2
[5] Fraden, J.: Handbook of Modern Sensors. 3rd ed., Springer Verlag 2004
[6] Harsanyi, G.: Sensors in Biomedical Applications. Fundamentals, Technology & Applications. CRC Press, Boca Raton 2000
[7] Prasad, P.N.: Introduction to Biophotonics, Wiley, 2003, ISBN 0-471-29770-9
Keywords:
Optoelectronical sensors, interaction of photons with biotissue, tissue optics, Monte Carlo and Kubelka-Munk simulation strategies, modelling of blood circulation system, non-invasive detection of peripheral venous and arterial hemodynamics, optical imaging techniques.