The study subject links to Anatomy and Physiology II and is dedicated to excitable tissues (muscles and neural system) in the terms of signal generation, measuring possibilities and exploitation of changes in electrical parameters. Signal generation is explained at cellular and molecular levels, different software simulations are employed. From the methodological point of view, measurements of electrical parameters are described at all levels - cells, tissues, organs. Exploitation of electrical parameters of cells, tissues and organs is treated from both clinical and experimental points. Methods to use electrical field or stimulation for medical purposes are described. Besides lectures, practical classes focused on independent study of students are incorporated into the syllabus.
1. General neurophysiology - introduction, history, membrane of excitable tissues. action and resting membrane potential, nerve and synapse.
2.Heart and ECG - history, signal generation, typical ECG curve, clinical use.
3.Brain and EEG - history, signal generation, brain wave rhythms, clinical use, sleep/wake cycle.
4.Other use of electrophysiology in research and clinical practise - pain and epilepsy diagnosis and treatment, patch-clamp, voltage-clamp, single unit recording, evoked potentials.
 Ambler Z.: Základy neurologie, Galén, Karolinum, 2006
 Ambler Z., Bednarík J., Ruzicka E. et al.: Klinická neurologie, Triton, 2008
 Ganong W.: Prehled lékarské fyziologie, 2008
 Hovorka J., Nezádal T. et al.: Klinická enecefalografie, Maxdorf , 2003
 Silbernagel, S., Depopulos, A.Q.: Atlas fyziologie cloveka, Grada 2003
 Rozman et al.: Elektronické prístroje v lékarství, Academia, Praha 2006