Code: 17ABBELF Electrophysiology
Lecturer: prof. MUDr. Pavel Kučera Ph.D. Weekly load: 1+1 Assessment: Z,ZK
Department: 17110 Credits: 4 Semester: W
The study subject links to Anatomy and Physiology II and is dedicated to excitable tissues (muscles and neural system) in the terms of signal generation, measuring possibilities and exploitation of changes in electrical parameters. Signal generation is explained at cellular and molecular levels, different software simulations are employed. From the methodological point of view, measurements of electrical parameters are described at all levels - cells, tissues, organs. Exploitation of electrical parameters of cells, tissues and organs is treated from both clinical and experimental points. Methods to use electrical field or stimulation for medical purposes are described. Besides lectures, practical classes focused on independent study of students are incorporated into the syllabus.
1. General neurophysiology - introduction, history, membrane of excitable tissues. action and resting membrane potential, nerve and synapse.
2.Heart and ECG - history, signal generation, typical ECG curve, clinical use.
3.Brain and EEG - history, signal generation, brain wave rhythms, clinical use, sleep/wake cycle.
4.Other use of electrophysiology in research and clinical practise - pain and epilepsy diagnosis and treatment, patch-clamp, voltage-clamp, single unit recording, evoked potentials.
Recommended literature:
[1] Ambler Z.: Základy neurologie, Galén, Karolinum, 2006
[2] Ambler Z., Bednarík J., Ruzicka E. et al.: Klinická neurologie, Triton, 2008
[3] Ganong W.: Prehled lékarské fyziologie, 2008
[4] Hovorka J., Nezádal T. et al.: Klinická enecefalografie, Maxdorf , 2003
[5] Silbernagel, S., Depopulos, A.Q.: Atlas fyziologie cloveka, Grada 2003
[6] Rozman et al.: Elektronické prístroje v lékarství, Academia, Praha 2006

[7]Literatura doporucená
[8]. Pieck J et al.: Grundlagen neurochirurgischer Intensivmedizin, Zuckschwerdt Verlag, 1999